Hormone Panel
Free testosterone, DHEA-S, estradiol, and SHBG together — the baseline for any hormone conversation.
What it does
Free testosterone, DHEA-S, estradiol, and SHBG together — the baseline for any hormone conversation. SHBG determines how much of the hormone is biologically active.
SHBG binds sex hormones and determines how much is biologically active; reading free testosterone, DHEA-S, and estradiol alongside SHBG distinguishes a true deficiency from a binding-protein artifact.
What the evidence shows
Overall evidence strength: Moderate certainty
Who it's for, who should skip
Anyone considering a hormone conversation. Interpret each marker against its own sex/age reference range; a single borderline reading is not grounds for therapy — symptoms and repeat testing matter.
Running it
Measuring it
Retest Free Testosterone — Free testosterone is a diagnostic adjunct when SHBG is off — no guideline retest cadence. On therapy, total testosterone is the monitored marker..
Stacking & alternatives
Access & cost
Ordered as a lab test through the bloodwork lane.
Last reviewed 27 August 2026.